HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 258745Erstellt: 24. Oktober 2026
Hydrochloric Acid → N-Methyl-N'-methylamino-N"-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidine dihydrochloride
https://huagongshe.com/de/reaction/258745
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Hydrochloric Acid | HCID 313 | — |
| Edukt | Potassium Bicarbonate | HCID 516893 | — |
| Edukt | N-methyl-N-tert-butoxycarbonylhydrazine sulphate | HCID 88794812 | — |
| Edukt | HCID 178485010 | HCID 178485010 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | N-Methyl-N'-methylamino-N"-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidine dihydrochloride | HCID 178486240 | — |
Reaktionsschritte
A mixture of the isothiourea dihydrochloride of Example 1 (i) (6.7 g), N-methyl-N-tert-butoxycarbonylhydrazine sulphate (5.7 g), potassium hydrogen carbonate (10.0 g) and anhydrous dimethylformamide (80 ml) was stirred at 90° C. for 3 hours. After cooling, filtration and concentration to yield the free base, this was heated under reflux with ethanolic hydrogen chloride. Concentration and trituration of the residual product yielded the title compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US04034101 |
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| Quelldatensatz | uspto-grants-1977_07 |
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| ORD ID | ord-ae33860c3be94f0fa9214fab10a9ef6e |
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| Quellennotiz | uspto-grants-1977_07 |
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