Dimethylformamide → HCID 178422953, Verbindung

HRID 267505

Reaktionsgleichung

Reaktionsgleichung von HRID 267505
[CH3:1][C:2]1[N:11]=[C:10]2[C:5]([C:6](=[O:15])[C:7]([C:12](O)=O)=[CH:8][NH:9]2)=[CH:4][CH:3]=1.[NH2:16][C:17]1[NH:21][N:20]=[N:19][N:18]=1.CN(C)[CH:24]=[O:25]>>[CH3:1][C:2]1[N:11]=[C:10]2[C:5]([C:6](=[O:15])[C:7]([CH2:12][C:24]([NH:16][C:17]3[NH:21][N:20]=[N:19][N:18]=3)=[O:25])=[CH:8][NH:9]2)=[CH:4][CH:3]=1

Komponenten

4

Edukt 3

HCID 6228DimethylformamideHCID 53736724-Hydroxy-7-methyl-1,8-naphthyridine-3-carboxylic acidHCID 178509299HCID 178509299, Verbindung

Produkt 1

HCID 178422953HCID 178422953, Verbindung

Versuchsvorschrift

1,4-Dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid (4 g) and N,N'-carbonyldiimidazole (3.5 g) in dimethylformamide (40 ml) were heated at 80° for 6 hours. 5-Amino-1H-tetrazole (2.5 g) was added and the mixture was stirred and heated at 80° for 1.5 hours. The solid was collected and dissolved in aqueous sodium hydroxide. The solution was acidified with glacial acetic acid and the solid was collected and dried. It had m.p. 344°-345.5°, (47%)

Aufarbeitung

  1. temperatureheated at 80° for 1.5 hours
  2. customThe solid was collected
  3. dissolutiondissolved in aqueous sodium hydroxide
  4. customthe solid was collected
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-d798cd99aa324fcf9bd1f12ba2b3a220
Quelldatensatz
uspto-grants-1976_03
Patentnummer
US03943141

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