Triphenylphosphonium bromide → HCID 24755049, Verbindung

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

To a solution of 1-(4-fluoro-phenyl)-5-hydroxymethyl-4-isopropyl-1H-pyrazole-3-carboxylic acid benzylamide (0.525 g, 1.43 mmol) in acetonitrile (50 mL) was added triphenylphosphine hydrobromide (0.49 g, 1.43 mmol; commercially available from Sigma Aldrich). The reaction was heated to 80° C. for 24 hr after which time all starting material was consumed as determined by TLC. The reaction solvent was removed under reduced pressure and the resulting white solid was dried under high vacuum for 12 hr to provide [5-benzylcarbamoyl-2-(4-fluoro-phenyl)-4-isopropyl-2H-pyrazol-3-ylmethyl]-triphenyl-phosphonium bromide (0.977 g, 98%) in sufficient purity for use in the next step.

Herkunft & Nachweise