HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-(3-Phenylpropyl)piperidine → 1-(2,5-Difluoro-4-methoxyphenyl)-4-(3-phenylpropyl)piperidine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-(3-Phenylpropyl)piperidine | HCID 87678 | — |
| Edukt | 4-Bromo-1-methoxy-2-methylbenzene | HCID 608315 | — |
| Edukt | 4-Bromo-2,5-difluoroanisole | HCID 2724983 | — |
| Produkt | 1-(2,5-Difluoro-4-methoxyphenyl)-4-(3-phenylpropyl)piperidine | HCID 23111506 | 33,7% |
Reaktionsschritte
Production Example 9 was repeated except that 5-bromo-2-methoxytoluene and 1-(2-phenethyl)piperazine were replaced with 4-bromo-2,5-difluoroanisole (446 mg) and 4-(3-phenylpropyl)-piperidine (1.220 g), respectively. The resulting crude product was purified on silica gel column chromatography (eluent, hexane: ethyl acetate=8:1) to provide 1-(2,5-difluoro-4-methoxyphenyl)-4-(3-phenylpropyl)piperidine (233 mg).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07449466B2 |
| Quelldatensatz | uspto-grants-2008_11 |
| ORD ID | ord-d6123d46385f408a9055741a7d9c4e2a |
| Quellennotiz | uspto-grants-2008_11 |