HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-Chlorobenzenesulfonyl chloride → 3-Cyanomethyl-1-(4-chlorophenylsulfonyl)pyrrolidine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-Chlorobenzenesulfonyl chloride | HCID 7398 | — |
| Edukt | Triethylamine | HCID 8471 | — |
| Edukt | 2-(Pyrrolidin-3-yl)acetonitrile hydrochloride | HCID 20078139 | — |
| Lösungsmittel | Chloroform | HCID 6212 | — |
| Produkt | 3-Cyanomethyl-1-(4-chlorophenylsulfonyl)pyrrolidine | HCID 20078166 | 101,1% |
Reaktionsschritte
Acylation, in chloroform, of 36.6 g (0.25 mol) of 3-cyanomethylpyrrolidine hydrochloride with 52.7 g (0.25 mol) of para-chlorophenylsulfonic acid chloride, in the presence of 50.5 g (0.5 mol) of triethylamine makes it possible to obtain 72 g of a solid which is purified by chromatography on silica, Merck 70-230 mesh, using as eluent a dichloromethane/methanol mixture (99/1 v/v).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05387591 |
| Quelldatensatz | uspto-grants-1995_02 |
| ORD ID | ord-f57e2c7f26ac4a6085f3586e6f76abbd |
| Quellennotiz | uspto-grants-1995_02 |