3,5-Diiodosalicylic acid → HCID 23323149, Verbindung

HRID 280037

Reaktionsgleichung

Reaktionsgleichung von HRID 280037
[I:1][C:2]1[CH:10]=[C:9]([I:11])[CH:8]=[C:4]([C:5]([OH:7])=O)[C:3]=1[OH:12].[NH2:13][C:14]1[CH:19]=[C:18]([CH3:20])[C:17]([C:21]([C:23]2[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=2)=[CH2:22])=[C:16]([Cl:30])[CH:15]=1.P(Cl)(Cl)Cl>>[Cl:30][C:16]1[CH:15]=[C:14]([NH:13][C:5](=[O:7])[C:4]2[CH:8]=[C:9]([I:11])[CH:10]=[C:2]([I:1])[C:3]=2[OH:12])[CH:19]=[C:18]([CH3:20])[C:17]=1[C:21]([C:23]1[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=1)=[CH2:22]

Komponenten

4

Edukt 3

HCID 86313,5-Diiodosalicylic acidHCID 24387Phosphorus trichlorideHCID 23323150HCID 23323150, Verbindung

Produkt 1

HCID 23323149HCID 23323149, Verbindung

Versuchsvorschrift

Using the reaction sequence of Example 4, 3,5-diiodosalicylic acid is reacted with 1-(4-amino-2-chloro-6-methylphenyl)-1-(4-chlorophenyl)ethylene in the presence of phosphorus trichloride to give N-[3-chloro-5-methyl-4-[1-(4-chlorophenyl)ethenyl]phenyl]-3,5-diiodo-2-hydroxybenzamide. The benzophenone used as starting material for the Wittig reaction was prepared by reacting 4-chlorobenzyl cyanide with 3-chloro-5-methyl-1-nitrobenzene followed by oxidation with alkaline peroxide as known in the literature.

Quellen und Nachweise

ORD-Eintrag
ord-91459bcd657c4ad9b89aeb1ee04995d5
Quelldatensatz
uspto-grants-1986_05
Patentnummer
US04587361

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