HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Aluminum isopropoxide → Thiazole, 5-(methoxymethyl)-4-methyl-
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Aluminum isopropoxide | HCID 11143 | — |
| Edukt | Sodium hydride | HCID 24758 | — |
| Edukt | 4-Methylthiazole-5-carboxaldehyde | HCID 581339 | — |
| Lösungsmittel | Isopropanol | HCID 3776 | — |
| Lösungsmittel | Methyl iodide | HCID 6328 | — |
| Lösungsmittel | 1,2-Dimethoxyethane | HCID 8071 | — |
| Produkt | Thiazole, 5-(methoxymethyl)-4-methyl- | HCID 11571819 | — |
Reaktionsschritte
4-Methyl-5-thiazolecarbaldehyde (J. Amer. Chem. Soc., 1982, 104, 4934-4943) was reduced using aluminium isopropoxide in 2-propanol. The resulting alcohol was treated with sodium hydride in dimethoxyethane and iodomethane was added. Distillation gave the title compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05731335 |
| Quelldatensatz | uspto-grants-1998_03 |
| ORD ID | ord-7f93372015354dc38e885820152952ed |
| Quellennotiz | uspto-grants-1998_03 |