HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-Chlorophenol → 1-Methyl-2-(2-p-chlorophenoxyethyl)-piperidine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-Chlorophenol | HCID 4684 | — |
| Edukt | Sodium Hydroxide | HCID 14798 | — |
| Edukt | 2-(2-Chloroethyl)-1-methylpiperidine | HCID 3016566 | — |
| Katalysator | Benzyl triethylammonium chloride | HCID 66133 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | 1-Methyl-2-(2-p-chlorophenoxyethyl)-piperidine | HCID 23339173 | — |
Reaktionsschritte
200 ml of 50% aqueous sodium hydroxide solution and 1 g of triethylbenzylammonium chloride are added to a solution of 12.8 g of p-chlorophenol in 100 ml of CH2Cl2 ; 16.2 g of 1-methyl-2-(2-chloroethyl)-piperidine are added dropwise, while stirring; and the reaction mixture is stirred for a further one hour. After customary working up, 1-methyl-2-(2-p-chlorophenoxyethyl)-piperidine is obtained. Hydrochloride, m.p. 139°-140°.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04225608 |
| Quelldatensatz | uspto-grants-1980_09 |
| ORD ID | ord-2812348ef1c64c43accd809c79458783 |
| Quellennotiz | uspto-grants-1980_09 |