HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1,3-Dichloroacetone → 2-(5-Bromo-4-methyl-2-thienyl)-4-chloromethyloxazole
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1,3-Dichloroacetone | HCID 10793 | — |
| Edukt | 5-Bromo-4-methylthiophene-2-carboxamide | HCID 22009668 | — |
| Produkt | 2-(5-Bromo-4-methyl-2-thienyl)-4-chloromethyloxazole | HCID 22009708 | 53% |
Reaktionsschritte
In substantially the same manner as in Reference Example 47, 5-bromo-4-methyl-2-thiophenecarboxamide was allowed to react with 1,3-dichloroacetone to give 2-(5-bromo-4-methyl-2-thienyl)-4-chloromethyloxazole. The yield was 53%. Recrystallization from ethyl acetate-hexane gave clolorless prisms, mp 71-72° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06211215B1 |
| Quelldatensatz | uspto-grants-2001_04 |
| ORD ID | ord-ee9cbf52665b4d95b55b26e7429ee636 |
| Quellennotiz | uspto-grants-2001_04 |