Hydrochloric Acid → 3-[4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethylthio]phenyl]propanol

Beteiligte Stoffe

Reaktionsschritte

To a solution of ethyl 3-[4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethylthio]phenyl]propionate (205 mg) in tetrahydrofuran (10 ml) was added lithium aluminum hydride at 0° C. and then stirred for one hour at room temperature. To the reaction mixture were added water and 1N-hydrochloric acid, and extracted with ethyl acetate. The ethyl acetate layer was washed with water, dried (MgSO4), and concentrated under reduced pressure to give crystals of 3-[4-[2-[(E)-2-phenyl ethenyl]-4-oxazolylmethylthio]phenyl]propanol (135 mg, 77%). Recrystallization from ethyl acetate-hexane gave colorless needles, mp 91-92° C.

Herkunft & Nachweise