HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-(Chloromethyl)-2-phenyl-1,3-oxazole → 4-[3-[3-(1-Imidazolyl)propyl]phenoxymethyl]-2-phenyloxazole
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-(Chloromethyl)-2-phenyl-1,3-oxazole | HCID 3551196 | — |
| Edukt | 1-[3-(3-Hydroxyphenyl)propyl]imidazole | HCID 22009809 | — |
| Produkt | 4-[3-[3-(1-Imidazolyl)propyl]phenoxymethyl]-2-phenyloxazole | HCID 22009794 | 78% |
Reaktionsschritte
In substantially the same manner as in Working Example 72, 1-[3-(3-hydroxyphenyl)propyl]imidazole was allowed to react with 4-chloromethyl-2-phenyloxazole to give 4-[3-[3-(1-imidazolyl)propyl]phenoxymethyl]-2-phenyloxazole. The yield was 78%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 62-63° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06211215B1 |
| Quelldatensatz | uspto-grants-2001_04 |
| ORD ID | ord-ee5044c8a3364c0ea2967013ad80aeb4 |
| Quellennotiz | uspto-grants-2001_04 |