HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 323213Erstellt: 24. Oktober 2026
Hydrogen Bromide → (1H-benzimidazol-2-yl)(piperidin-4-yl)amine hydriodic acid
https://huagongshe.com/de/reaction/323213
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Hydrogen Bromide | HCID 260 | — |
| Edukt | Hydrogen iodide | HCID 24841 | — |
| Edukt | 1-Piperidinecarboxylic acid, 4-(1H-benzimidazol-2-ylamino)-, ethyl ester | HCID 3018455 | — |
| Produkt | (1H-benzimidazol-2-yl)(piperidin-4-yl)amine hydriodic acid | HCID 86754231 | — |
Reaktionsschritte
Combine (1H-benzimidazol-2-yl)-(1-ethoxycarbonyl-piperidin-4-yl)amine (4.63 g, 16 mmol) and 48% hydrobromic acid (75 mL). Heat to reflux. After 1.5 hours, cool and evaporate in vacuo to give a solid. Add 47% hydriodic acid (30 mL) and heat at about 90° C. After 30 minutes cool to obtain a solid. Collect the solid by filtration, rinse with ethanol and diethyl ether, and dry to give the title compound: mp; >290° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US06211199B1 |
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| Quelldatensatz | uspto-grants-2001_04 |
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| ORD ID | ord-97691acebaf24ddab33abb9408c6041d |
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| Quellennotiz | uspto-grants-2001_04 |
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