Triethylamine → Fmoc-p-Me-D-Phe-OMe

Beteiligte Stoffe

Reaktionsschritte

Fmoc—p—Me—D—Phe—OH (5 g) was dissolved in dichloromethane/methanol 9/1 v/v (50 ml). 2-(1H-benzotriazol-1-yl 1,1,3,3-tetramethyluronium tetrafluoroborate (4.4 g) was added and the solution adjusted to pH 8 by addition of triethylamine. The reaction mixture was stirred for 16 hours at room temperature. The mixture was washed successively with cold 1N hydrochloric acid solution, water, 5% sodium hydrogencarbonate, and water and dried over sodium sulphate. The filtrate was evaporated yielding 5.6 g of Fmoc—p—Me—D—Phe—OMe as an oil.

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