(+-)-3,4-Dimethoxyamphetamine → 3-[3-(3,4-Dimethoxyphenyl)-2-propylamino]1,2-propanediol

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

A solution of 3-(3,4-dimethoxyphenyl)-2-propylamine (20.0 g., 0.10 m.) in isopropanol (20 ml.) is heated to 50° C. while a solution of glycidol (5.0 g., 0.067 m.) in isopropanol (5ml.) is added over 15 minutes. The mixture is stirred at 50° C. for 0.5 hours and then at 70° C. for 16 hours. The solvent is concentrated under reduced pressure and the residue is chromatographed on silica gel, eluting with 10% MeOH-CHCl3 saturated with NH3 to yield (I) weighing 14.37 g. (80%).

Herkunft & Nachweise