Dicyclohexylcarbodiimide → N,N'-Dicyclohexylurea

Beteiligte Stoffe

Reaktionsschritte

A solution of 35.4 g of 4-(5-decylpyrimidin-2-yl)phenol, 22.5 g of trans-4-pentylcyclohexanecarboxylic acid and 23.4 g of N,N'-dicyclohexylcarbodiimide in 600 ml of dichloromethane is stirred at 20° C. for 12 hours. The N,N'-dicyclohexylurea formed is filtered off, and the filtrate is chromatographed over 5 kg of silica gel using dichloromethane. The product-containing fraction gives 21.5 g of colorless crystals after recrystallization from n-hexane.

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