HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-(5-Fluoro-pyridin-2-yl)-isoxazole-4-carboxylic acid ethyl ester → 3-(5-Fluoro-pyridin-2-yl)-isoxazole-4-carboxylic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-(5-Fluoro-pyridin-2-yl)-isoxazole-4-carboxylic acid ethyl ester | HCID 66643614 | — |
| Edukt | 3-Pyridin-2-yl-isoxazole-4-carboxylic acid ethyl ester | HCID 66643758 | — |
| Produkt | 3-(5-Fluoro-pyridin-2-yl)-isoxazole-4-carboxylic acid | HCID 67157810 | 67% |
Reaktionsschritte
As described for example 358b, 3-(5-fluoro-pyridin-2-yl)-isoxazole-4-carboxylic acid ethyl ester (1.0 g, 4.23 mmol) was converted, instead of 3-pyridin-2-yl-isoxazole-4-carboxylic acid ethyl ester, to the title compound (587 mg, 67%) which was obtained as a dark brown solid. MS: m/e=207.1 [M−H]−.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08877782B2 |
| Quelldatensatz | uspto-grants-2014_11 |
| ORD ID | ord-1db2ec08134d43b9b044ddfc53b3b42f |
| Quellennotiz | uspto-grants-2014_11 |