3-(3-Methoxypropoxy)-1-propanol → Ethyl 1-(2-methyl-4-quinolyl)piperidine-4-carboxylate

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

4-Chloroquinaldine (0.888 g, 5 mmol) and ethyl piperidine-4-carboxylate (1.18 g, 7.5 mmol) were mixed together with dipropyleneglycolmonomethylether (5 ml) and stirred at 150° C. for 48 hours. The solvent was removed under reduced pressure and the residue purified by column chromatography (pre-packed silica column, gradient of dichloromethane/ethyl acetate) to give 2.43 g of a brown oil that was used directly in the next step. MS (APCI): m/z=298.9 [M+1]+.

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