Triethylamine → (R)-N-(1-aminopropan-2-yl)isoquinoline-6-sulfonamide dihydrochloride

Beteiligte Stoffe

Reaktionsschritte

(R)-tert-butyl 2-aminopropylcarbamate (338 mg) synthesized according to the method described in PCT publication No. WO2010/006085 was condensed with isoquinoline-6-sulfonyl chloride prepared in Reference Example 1 in the presence of triethylamine (0.538 mL) in dichloromethane to obtain a crude product. Subsequently, 252 mg of the title compound was obtained as a white solid (38%) with reference to the methods of Steps 2 and 3 of Example 1.

Herkunft & Nachweise