HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-[(4-fluorophenyl)methyl]-4-methoxy-2-methyl-1H-indole → 1-[(4-fluorophenyl)methyl]-4-hydroxy-2-methyl-1H-indole
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-[(4-fluorophenyl)methyl]-4-methoxy-2-methyl-1H-indole | HCID 10825849 | — |
| Edukt | Boron tribromide dichloromethane | HCID 22277759 | — |
| Produkt | 1-[(4-fluorophenyl)methyl]-4-hydroxy-2-methyl-1H-indole | HCID 10753503 | 84,2% |
Reaktionsschritte
By the method used in Example 1, Part D, 1.1 g (4.1 mmol) of 1-[(4-fluorophenyl)methyl]-4-methoxy-2-methyl-1H-indole was O-demethylated by treating it with 16.4 mL of 1M BBr3 /CH2Cl2 to give 881 mg (84% yield) of crude 1-[(4-fluorophenyl)methyl]-4-hydroxy-2-methyl-1H-indole.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05733923 |
| Quelldatensatz | uspto-grants-1998_03 |
| ORD ID | ord-858e366b919f470e923529fff24917ea |
| Quellennotiz | uspto-grants-1998_03 |