HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-cyclopropyl-4-methoxy-1-(phenylmethyl)-1H-indole → 2-cyclopropyl-4-hydroxy-1-(phenylmethyl)-1H-indole
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-cyclopropyl-4-methoxy-1-(phenylmethyl)-1H-indole | HCID 10516668 | — |
| Edukt | Boron tribromide dichloromethane | HCID 22277759 | — |
| Produkt | 2-cyclopropyl-4-hydroxy-1-(phenylmethyl)-1H-indole | HCID 10491805 | 52,2% |
Reaktionsschritte
By the method used in Example 1, Part D, 630 g (2.3 mmol) of 2-cyclopropyl-4-methoxy-1-(phenylmethyl)-1H-indole was O-demethylated by treating it with 9 mL of 1M BBr3 /CH2Cl2. The crude product was chromatographed on silica gel and eluted with 20% EtOAc/hexane to give 316 mg (52% yield) of 2-cyclopropyl-4-hydroxy-1-(phenylmethyl)-1H-indole as an oil.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05733923 |
| Quelldatensatz | uspto-grants-1998_03 |
| ORD ID | ord-90e6c368bccf4e26954b7d2f6022a3b3 |
| Quellennotiz | uspto-grants-1998_03 |