Ammonium formate → 4-(5-(Pyridin-4-yl)oxazol-4-yl)phenol

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

To a solution of 4-(4-(4-(Benzyloxy)phenyl)oxazol-5-yl)pyridine (300 g, 0.91 mmol) was added 20% Pd(OH)2/C (30 mg) and ammonium formate (115 mg, 1.83 mmol) in methanol (8 mL ). The solution was heated at 60° C. for 20 min. The catalyst was removed by filtration and the filtrate was concentrated to give 208 mg (96%) of the title compound. 1H NMR (400 MHz, CDCl3) δ: 6.92 (m, 2H), 7.46 (m, 2H), 7.57 (d, 2H), 8.02 (s, 1H), 8.58 (m, 2H). MS m/z: 239 [M+1]+.

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