HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Trifluoroacetic acid → HCID 178520662, Verbindung
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Trifluoroacetic acid | HCID 6422 | — |
| Edukt | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Edukt | Thiomorpholine 1-oxide | HCID 12600299 | — |
| Edukt | 6-chloro-4-[1-(1-tert.-butyloxycarbonyl-5-chloro-1H-benzimidazol-2-yl)-3-hydroxycarbonyl-propyl-amino]-7-(pyrrolidin-1-yl-carbonyl)-quinazoline | HCID 68938489 | — |
| Lösungsmittel | Acetonitrile tetrahydrofuran | HCID 22177404 | — |
| Produkt | HCID 178520662 | HCID 178520662 | — |
Reaktionsschritte
Prepared analogously to Example 61 from 6-chloro-4-[1-(1-tert.-butyloxycarbonyl-5-chloro-1H-benzimidazol-2-yl)-3-hydroxycarbonyl-propyl-amino]-7-(pyrrolidin-1-yl-carbonyl)-quinazoline and thiomorpholine-1-oxide with TBTU in acetonitrile/tetrahydrofuran and subsequent reaction with trifluoroacetic acid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07429597B2 |
| Quelldatensatz | uspto-grants-2008_09 |
| ORD ID | ord-611744ac6c9549ffb0b0b7f338c8ebf5 |
| Quellennotiz | uspto-grants-2008_09 |