HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Benzyl Chloride → Methyl 2-(4-benzyloxyphenyl)acetate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Benzyl Chloride | HCID 7503 | — |
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | Sodium Hydroxide | HCID 14798 | — |
| Edukt | Benzeneacetic acid, 4-hydroxy-, methyl ester | HCID 518900 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Produkt | Methyl 2-(4-benzyloxyphenyl)acetate | HCID 2756645 | — |
Reaktionsschritte
Methyl 4-hydroxyphenylacetate (5, 0.2 mol), obtainable from Aldrich Chemical Co. Inc., Milwaukee, Wis., is heated at reflux with benzyl chloride (25 g, 0.2 mol) and K2CO3 (25 g, 0.2 mol) in 100 mL ethanol. The product is added to dilute aqueous NaOH, extracted with ether, and purified by silica gel chromatography to yield methyl 4-benzyloxyphenylacetate (6). (Scheme II, Step 1.)
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04761420 |
| Quelldatensatz | uspto-grants-1988_08 |
| ORD ID | ord-9c76812738bd47cb8d4850477591476a |
| Quellennotiz | uspto-grants-1988_08 |