HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Diethyl Malonate → diethyl (S)-2-methylbutylmalonate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Diethyl Malonate | HCID 7761 | — |
| Edukt | Sodium | HCID 5360545 | — |
| Edukt | 1-Bromo-2-methylbutane, (+)- | HCID 5464167 | — |
| Edukt | Sodium Methoxide | HCID 10942334 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Produkt | diethyl (S)-2-methylbutylmalonate | HCID 12600622 | — |
Reaktionsschritte
Sodium (57.5 g, 2.5 mols) was added to ethanol (1 l) to prepare sodium methoxide, followed by adding (S)-2-methylbutyl bromide (317 g, 2.1 mols) and diethyl malonate 400 g, 2.5 mols), refluxing the mixture for 5 hours and distilling off ethanol to obtain oily diethyl (S)-2-methylbutylmalonate.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05059340 |
| Quelldatensatz | uspto-grants-1991_10 |
| ORD ID | ord-98696a3edf844093a91efe5755259a25 |
| Quellennotiz | uspto-grants-1991_10 |