1-(Thien-2-ylcarbonyl)piperazine → 1-Methyl-2-Oxo-4-[4-(Thiophen-2-Ylcarbonyl)piperazin-1-Yl]-1,2-Dihydroquinoline-3-Carbonitrile

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

Piperazine-1-yl-thiophen-2-yl-methanone (600 mg, 3.06 mmol) was added to a solution of Compound 3 (319 mg, 1.46 mmol) in toluene (40 mL) and heated overnight at 120° C. The solvent was removed under vacuum. The residue was suspended in water, sonicated, and filtered to yield 540 mg (98%) of white solids. M.P. 247° C. 1H NMR (DMSO-d6): δ 3.58 (s, 3H), 3.63 (m, 4H), 3.92 (m, 4H), 7.16 (t, J=4.8 Hz, 1H), 7.33 (t, J=7.5 Hz, 1H), 7.48 (d, J=3.5 Hz, 1H), 7.59 (d, J=8.5 Hz, 1H), 7.75 (t, J=7.25, 2H), 7.79 (d, J=4.8 Hz, 1H) 7.92 (d, J=7.5 Hz, 1H). EIMS m/z 379 (M+1), 401 (M+23). Anal. (C20H18N4O2S) C, H, N.

Herkunft & Nachweise