Hydrochloric Acid → 4-[(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)methyl]-2-furaldehyde

HRID 347316

Reaktionsgleichung

Reaktionsgleichung von HRID 347316
[CH3:1][C:2]1([CH3:25])[CH2:11][CH2:10][C:9]([CH3:13])([CH3:12])[C:8]2[CH:7]=[C:6]([CH2:14][C:15]3[CH:16]=[C:17]([CH:20]4OCC[O:21]4)[O:18][CH:19]=3)[CH:5]=[CH:4][C:3]1=2.Cl>C1COCC1>[CH3:1][C:2]1([CH3:25])[CH2:11][CH2:10][C:9]([CH3:12])([CH3:13])[C:8]2[CH:7]=[C:6]([CH2:14][C:15]3[CH:16]=[C:17]([CH:20]=[O:21])[O:18][CH:19]=3)[CH:5]=[CH:4][C:3]1=2

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 21082601HCID 21082601, Verbindung

Produkt 1

HCID 210826444-[(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)methyl]-2-furaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A round bottom flask was mixed with 2-{4-[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro- 2-naphthalenyl)methyl]-2-furyl}-1,3-dioxolane (246 mg, 0.72 mmol), 3.0 N HCl (10 mL) and THF (20 mL). The reaction mixture stirred for 16 hours at room temperature and was concentrated to one half volume. The resulting mixture was partitioned between saturated NaCl and ether. The ether layer was dried over MgSO4 and concentrated to dryness. The resulting oil showed an inseparable impurity by TLC and the product was used without further purification.

Aufarbeitung

  1. concentrationwas concentrated to one half volume
  2. customThe resulting mixture was partitioned between saturated NaCl and ether
  3. dry with materialThe ether layer was dried over MgSO4
  4. concentrationconcentrated to dryness
  5. customthe product was used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-bce71868654642e69db07a6b4dc933fd
Quelldatensatz
uspto-grants-2007_02
Patentnummer
US07173134B2

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