Potassium Carbonate → Codeine

Beteiligte Stoffe

Reaktionsschritte

Morphine of purity 35% 815 parts (1 mole parts), potassium carbonate 552 parts (4 moles part) and trimethylphenyl-ammonium chloride 188 parts (1.1 moles part) are heated under stirring in toluene (5000 parts) at 45° to 120° C. for 2 to 5 hrs. to yield 296 parts codeine (99% yield), after workup as in Example 1.

Herkunft & Nachweise