HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Potassium Carbonate → Codeine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | Morphine | HCID 5288826 | — |
| Katalysator | Phenyltrimethylammonium chloride | HCID 67309 | — |
| Lösungsmittel | Toluene | HCID 1140 | — |
| Produkt | Codeine | HCID 5284371 | 98% |
Reaktionsschritte
Morphine of 89% purity 320 parts (1 mole part), potassium carbonate 414 parts (3 moles part) and trimethylphenyl-ammonium chloride 188 parts (1.1 moles part) are heated under stirring in toluene (4000 parts) at 45°-110° C. for 3-8 hrs. to yield 293 parts of codeine (98.0% yield), after workup as in Example 1.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04764615 |
| Quelldatensatz | uspto-grants-1988_08 |
| ORD ID | ord-63cc52c60dae41f2b09880a3ea603c87 |
| Quellennotiz | uspto-grants-1988_08 |