HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-(1,3-Benzodioxol-5-yloxy)pyridine-3-carboxylic acid → (+)-2-[4-({[2-(Benzo[2,1,3]thiadiazol-5-yloxy)-pyridine-3-carbonyl]-amino}-methyl)-3-fluoro-phenoxy]-propionic acid tert-butyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-(1,3-Benzodioxol-5-yloxy)pyridine-3-carboxylic acid | HCID 2736879 | — |
| Edukt | Methyl 2-[4-(aminomethyl)-3-fluorophenoxy]acetate | HCID 18174008 | — |
| Edukt | 2-(Benzo[2,1,3]thiadiazol-5-yloxy)-nicotinic acid | HCID 22610159 | — |
| Edukt | (+)-2-(4-Aminomethyl-3-fluoro-phenoxy)-propionic acid tert-butyl ester | HCID 23529364 | — |
| Produkt | (+)-2-[4-({[2-(Benzo[2,1,3]thiadiazol-5-yloxy)-pyridine-3-carbonyl]-amino}-methyl)-3-fluoro-phenoxy]-propionic acid tert-butyl ester | HCID 23529360 | — |
Reaktionsschritte
The compound of Formula (5.0.27) was prepared in a manner analogous to that described in Preparation 20, substituting 2-(benzo[2,1,3]thiadiazol-5-yloxy)-nicotinic acid and (+)-2-(4-aminomethyl-3-fluoro-phenoxy)-propionic acid tert-butyl ester for the corresponding 2-(benzo-[1,3]-dioxol-5-yloxy)-nicotinic acid and (4-aminomethyl-3-fluoro-phenoxy)-acetic acid methyl ester materials, respectively.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07183293B2 |
| Quelldatensatz | uspto-grants-2007_02 |
| ORD ID | ord-1aab8af1c7a04bd29b59d1e2942d1556 |
| Quellennotiz | uspto-grants-2007_02 |