Hexahydro-1H-azepine-1-ethanol → 2-Homopiperidinylethyl 2-(7-trifluoromethyl-4-quinolyl)aminobenzoate

Beteiligte Stoffe

Reaktionsschritte

By treating 17.31 g of methyl 2-(7-trifluoromethyl-4-quinolyl)aminobenzoate (II, R=CF3, R"=CH3), 10.5 g of 1-(2-hydroxyethyl)homopiperidine in 130 ml of toluene and in the presence of sodium as described in Example 1, 20.6 g of a crude material are isolated. The recrystallization in diisopropyl ether enables to isolate 13.7 g (yield: 60%) of a whitish solid with m.p. 72°-75° C. and elemental analysis C, H, N, F correct.

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