Dimethylcarbamoyl Chloride → 4-[[(1-Piperidinyl)methylene]amino]-3-pyridinol N,N-dimethylcarbamate

Beteiligte Stoffe

Reaktionsschritte

A mixture prepared from 4-[[(1-piperidinyl)methylene]amino]-3-pyridinol (3.5 g), triethylamine (3.69 mL), dimethylcarbamyl chloride (2.3 mL) and tetrahydrofuran (130 mL) was refluxed for 2 hours, filtered, poured directly onto a silica column and eluted successively with ethyl acetate and 5% Et3N/ethyl acetate to yield 4.49 g of product. Recrystallization from ethyl acetate and drying under high vacuum yielded 3.94 g of crystals, m.p. 88°-89° C.

Herkunft & Nachweise