4-Fluorobenzoyl chloride → 4''-[3-Butyl-5-oxo-1-(2-trifluoromethyl-phenyl)-1,5-dihydro-[1,2,4]triazol-4-ylmethyl]-biphenyl-2-sulfonic acid 4-fluoro-benzoylamide

Beteiligte Stoffe

Reaktionsschritte

The title compound was prepared in 93% yield by reaction of 5-n-butyl-2,4-dihydro-4-[(2'-sulfamoylbiphenyl-4-yl)methyl]-2-[2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one (from Example 16, Step C) with 4-fluorobenzoyl chloride according to the procedure of Example 13, Step C. Column chromatography on silica gel (gradient elution with 0.5-5% MeOH in CH2Cl2) provided the material as cream-colored crystals, mp 120°-122° C.; satisfactory purity by TLC in 9:1 CH2Cl2 --MeOH; mass spectrum (FAB) m/e 691 (M+K)+.

Herkunft & Nachweise