p-Bromobenzenesulfonyl chloride → Diphenylmethyl 7-Phenoxyacetamido-3-[(4-bromophenylsulfonyl)oxy]-3-cephem-4-carboxylate

HRID 37351

Reaktionsgleichung

Reaktionsgleichung von HRID 37351
[O:1]([CH2:8][C:9]([NH:11][CH:12]1[C:36](=[O:37])[N:14]2[C:15]([C:20]([O:22][CH:23]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)=[O:21])=[C:16]([OH:19])[CH2:17][S:18][C@H:13]12)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Na+].[Br:40][C:41]1[CH:46]=[CH:45][C:44]([S:47](Cl)(=[O:49])=[O:48])=[CH:43][CH:42]=1>C(#N)C.[H][H]>[O:1]([CH2:8][C:9]([NH:11][CH:12]1[C:36](=[O:37])[N:14]2[C:15]([C:20]([O:22][CH:23]([C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)[C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)=[O:21])=[C:16]([O:19][S:47]([C:44]3[CH:45]=[CH:46][C:41]([Br:40])=[CH:42][CH:43]=3)(=[O:49])=[O:48])[CH2:17][S:18][C@H:13]12)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

6

Edukt 3

HCID 7396p-Bromobenzenesulfonyl chlorideHCID 24758Sodium hydrideHCID 67789034Diphenylmethyl 7-phenoxyacetamido-3-hydroxy-3-cephem-4-carboxylate

Produkt 1

HCID 88424480Diphenylmethyl 7-Phenoxyacetamido-3-[(4-bromophenylsulfonyl)oxy]-3-cephem-4-carboxylateAusbeute 54,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6342AcetonitrileLösungsmittelHCID 178418361HCID 178418361, VerbindungLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

The title compound was prepared via a modification of the synthesis described in U.S. Pat. No. 3,985,737. A solution of 0.51 g (0.001 mole) of diphenylmethyl 7-phenoxyacetamido-3-hydroxy-3-cephem- 4-carboxylate in 5 mL of acetonitrile was cooled to 0° C. under a nitrogen atmosphere. Then 0.030 g (0.001 mole) of sodium hydride (80% in mineral oil) was added resulting in hydrogen evolution. The reaction mixture was stirred at 0° C. for 5 minutes, and 0.229 g (0.009 mole) of 4-bromobenzenesulfonyl chloride was added. The cooling bath was removed, and the reaction mix stirred at room temperature for 19 hours. The reaction mixture was filtered and the filtrate carbon treated. The carbon was removed followed by the solvent to leave a foam residue. The residue was crystallized from 1-propanol to yield 0.398 g (54%) of the title compound.

Aufarbeitung

  1. customThe title compound was prepared via a modification of the synthesis
  2. customThe cooling bath was removed
  3. additionthe reaction mix
  4. stirringstirred at room temperature for 19 hours
  5. filtrationThe reaction mixture was filtered
  6. additionthe filtrate carbon treated
  7. customThe carbon was removed
  8. customto leave a foam residue
  9. customThe residue was crystallized from 1-propanol

Quellen und Nachweise

ORD-Eintrag
ord-874bd33f0e6a47ada2140eb2dce7b843
Quelldatensatz
uspto-grants-1995_05
Patentnummer
US05420269

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