HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Dimethylformamide → N-(1-ethylpyrazole-5-yl)-5-acetamidoanthranilic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Dimethylformamide | HCID 6228 | — |
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | 1-Ethyl-1H-pyrazol-5-amine | HCID 337310 | — |
| Edukt | 5-Acetamido-2-bromobenzoic acid | HCID 2734159 | — |
| Katalysator | Cupric acetate | HCID 8895 | — |
| Lösungsmittel | Acetic Acid | HCID 176 | — |
| Lösungsmittel | Water | HCID 962 | — |
| Produkt | N-(1-ethylpyrazole-5-yl)-5-acetamidoanthranilic acid | HCID 21217715 | 25,7% |
Reaktionsschritte
A mixture of 5-acetamido-2-bromobenzoic acid (7 g, 27 mmol), DMF (25 ml), Cu(OAc)2 (0.2 g), 5-amino-1-ethyl-pyrazole (3 g, 27 mmol) and K2CO3 (3.7 g, 27 mmol) was refluxed for about 2 days. The reaction mixture was poured into water, acidified with acetic acid and cooled. A solid formed which was collected by filtration to afford 2 g of N-(1-ethylpyrazole-5-yl)-5-acetamidoanthranilic acid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05488055 |
| Quelldatensatz | uspto-grants-1996_01 |
| ORD ID | ord-cdc0a5941aae4020a43435d52afd34bb |
| Quellennotiz | uspto-grants-1996_01 |