HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Dimethylformamide → N-(1-ethylpyrazol-5-yl)-5-bromoanthranilic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Dimethylformamide | HCID 6228 | — |
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | 2,5-Dibromobenzoic acid | HCID 11891 | — |
| Edukt | 1-Ethyl-1H-pyrazol-5-amine | HCID 337310 | — |
| Katalysator | Cupric acetate | HCID 8895 | — |
| Lösungsmittel | Acetic Acid | HCID 176 | — |
| Lösungsmittel | Water | HCID 962 | — |
| Produkt | N-(1-ethylpyrazol-5-yl)-5-bromoanthranilic acid | HCID 19592213 | 45,1% |
Reaktionsschritte
A mixture of 2,5-dibromobenzoic acid (25 g, 0.09 mol), DMF (200 ml), 5-amino-1-ethylpyrazole (10 g, 0.09 mol), Cu(OAc)2 (1 g) and K2CO3 (12.3 g, 0.09 mol) was heated at reflux for about 2 days. The reaction mixture was poured into water, acidified with acetic acid and the precipitate which formed was collected by filtration to afford 12.6 g of N-(1-ethylpyrazol-5-yl)-5-bromoanthranilic acid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05488055 |
| Quelldatensatz | uspto-grants-1996_01 |
| ORD ID | ord-0ac4e72bde0949cb889de7e43a5fb886 |
| Quellennotiz | uspto-grants-1996_01 |