Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Water | HCID 962 | — |
| Edukt | Benzyl Bromide | HCID 7498 | — |
| Edukt | Sodium Hydroxide | HCID 14798 | — |
| Edukt | Indole-3-acetonitrile | HCID 351795 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Produkt | 1-benzyl-1H-indol-3-ylacetonitrile | HCID 11032169 | — |
Reaktionsschritte
A mixture of 3-indolylacetonitrile (5 g, 32 mmol), triton B (40% in MeOH, 0.5 g), benzyl bromide (7. 8 mL, 2 eq.) and aqueous NaOH (50%, 12.6 mL) was stirred for 2 hours at 20° C. Water was added. Solid was collected by filtration and washed with water and hexane and dried under high vacuum to give [1-benzyl-1H-indol-3-yl]acetonitrile (6.97 g). MS (ES): 247 (MH+).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US08524704B2 |
|---|
| Quelldatensatz | uspto-grants-2013_09 |
|---|
| ORD ID | ord-08afda3e79734efdb85638397638806e |
|---|
| Quellennotiz | uspto-grants-2013_09 |
|---|
