Chlorotrimethylsilane → 1-Bromo-4-((trimethylsilyl)oxy)benzene

HRID 380279

Reaktionsgleichung

Reaktionsgleichung von HRID 380279
[CH3:1][Si:2](Cl)([CH3:4])[CH3:3].[Br:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=1>C1(C)C=CC=CC=1.N1C=CC=CC=1>[CH3:1][Si:2]([O:13][C:10]1[CH:11]=[CH:12][C:7]([Br:6])=[CH:8][CH:9]=1)([CH3:4])[CH3:3]

Komponenten

5

Edukt 2

HCID 6397ChlorotrimethylsilaneHCID 78084-Bromophenol

Produkt 1

HCID 873501-Bromo-4-((trimethylsilyl)oxy)benzene

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 1049PyridineLösungsmittelHCID 1140TolueneLösungsmittel

Versuchsvorschrift

Trimethylsilyl chloride (11 ml, 87 mmol) was added dropwise to a stirred solution of 4-bromophenol (10.0 g, 58 mmol) in toluene (25 ml) and pyridine (20 ml) at a 0° C. The stirred mixture was heated to ambient temperature during 3 hours. The reaction mixture was filtered and the organic solution evatorated to yield pure 4-bromophenyl trimethylsilyl ether. The silyl ether can be further purified by distillation (b.p. 122° C., 20 mmHg). Yield after distillation: 13.70 g (75%).

Aufarbeitung

  1. filtrationThe reaction mixture was filtered

Quellen und Nachweise

ORD-Eintrag
ord-cd170299f5ef41178017426d5087f10e
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06303101B1

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