Ethyl 2-methyl-4,4,4-trifluoroacetoacetate → Ethyl 2-methyl-3-hydroxy-4,4,4-trifluorobutyrate

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

Ethyl 2-methyl-4,4,4-trifluoroacetoacetate (50 g), under a blanket of nitrogen gas, is heated to 40° C. and treated with platinum (0.1 g of 5% Pt/C, 0.01% load) and triethylamine (0.2 g, 0.4 % load). Hydrogen is charged to a pressure of 5 bars, and the mixture agitated at 40° C. for 6h. After filtration to remove the catalyst, 48.5 g (96% yield) of ethyl 2-methyl-4,4,4-trifluoro-3-hydroxybutyrate is obtained.

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