HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 383680Erstellt: 24. Oktober 2026
3-(Propan-2-yloxy)aniline → 5-(3-Isopropoxyphenylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde
https://huagongshe.com/de/reaction/383680
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | 3-(Propan-2-yloxy)aniline | HCID 573220 | — |
| Edukt | 5-Chloropyrazolo(1,5-a)pyrimidine-3-carbaldehyde | HCID 58196401 | — |
| Lösungsmittel | 1,4-Dioxane | HCID 31275 | — |
| Produkt | 5-(3-Isopropoxyphenylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde | HCID 58196662 | — |
Reaktionsschritte
To 5-chloropyrazolo[1,5-a]pyrimidine-3-carbaldehyde (50 mg, 0.276 mmol) in dioxane was added 3-isopropoxyaniline (125 mg, 0.829 mmol). The mixture was heated in microwave for 20 minutes at 120° C. The solid produced was isolated by filtration and then purified by preparative TLC (2% MeOH/DCM) to yield 5-(3-isopropoxyphenylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde. LCMS (M+1=297)
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US08367681B2 |
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| Quelldatensatz | uspto-grants-2013_02 |
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| ORD ID | ord-0943c62de7e54027beef998dc3b3cde0 |
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| Quellennotiz | uspto-grants-2013_02 |
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