Water → 4-tert-Butyl 4'-methyl 2,6-diethoxybiphenyl-4,4'-dicarboxylate

https://huagongshe.com/de/reaction/38482

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Water	HCID 962	—
Edukt	Potassium Phosphate, Tribasic	HCID 62657	—
Edukt	4-Methoxycarbonylphenylboronic acid	HCID 2734369	—
Edukt	Tert-butyl 4-bromo-3,5-diethoxybenzoate	HCID 57930980	—
Katalysator	Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+)	HCID 178418228	—
Lösungsmittel	1,2-Dimethoxyethane	HCID 8071	—
Produkt	4-tert-Butyl 4'-methyl 2,6-diethoxybiphenyl-4,4'-dicarboxylate	HCID 67055556	—

Reaktionsbedingungen

Temperatur	100 °C

Reaktionsschritte

H2O (261 mg, 14.48 mmol) was added to a stirred mixture of PdCl2(dppf) (106 mg, 0.145 mmol), [4-(methoxycarbonyl)phenyl]boronic acid (626 mg, 3.48 mmol), tert-butyl 4-bromo-3,5-diethoxybenzoate (1.00 g, 2.90 mmol) and K3PO4 (1.23 g, 5.79 mmol) in DME (8 ml) and the mixture was stirred at 100° C. overnight. The reaction mixture was filtered through celite pad, the filtrate was concentrated under reduced pressure. The residue was purified by silicage column chromatography (hexane/EtOAc) to give intended compound as a colorless solid.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08524730B2
Quelldatensatz	uspto-grants-2013_09
ORD ID	ord-b276a56e587f4d9d87a49145d9afba45
Quellennotiz	uspto-grants-2013_09