Tetrabutylammonium Fluoride → 5-(1-Methyl-1H-1,2,3-triazol-4-yl)-2-{[6-(morpholin-4-ylmethyl)pyridin-2-yl]amino}thiophene-3-carboxamide

Beteiligte Stoffe

Reaktionsschritte

To a solution of 2-{[6-(morpholin-4-ylmethyl)pyridin-2-yl]amino}-5-{1-[(trimethylsilyl)methyl]-1H-1,2,3-triazol-4-yl}thiophene-3-carboxamide (65 mg, 0.14 mmol) in THF (2.0 mL) was added TBAF (1.0 M in THF, 0.276 ml, 0.276 mmol). The reaction was stirred at room temperature for 4 h. The solution was diluted with water and extracted with 5:1 CH2Cl2:MeOH (3×). The combined organic layers were dried (MgSO4), filtered, and evaporated. The crude solid was triturated with CH2Cl2 and filtered to isolate the title compound as a colorless solid.

Herkunft & Nachweise