HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 39034Erstellt: 24. Oktober 2026
Ammonia → [(2S)-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methylamine
https://huagongshe.com/de/reaction/39034
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
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| Edukt | Ammonia | HCID 222 | — |
| Edukt | [(2R)-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate | HCID 86652935 | — |
| Produkt | [(2S)-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methylamine | HCID 66878351 | — |
Reaktionsschritte
A mixture of [(2R)-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate (1.1 g, 2.5 mmol), NH3 (4 ml, 7N in methanol) was heated under microwave radiation at 120° C. for 20 min. The product was evaporated to dryness and was purified by flash column chromatography (EtOAc/MeOH). Yield 0.31 g. MS m/z (rel. intensity, 70 eV) 243 (M+, 35), 214 (bp), 199 (35), 79 (25), 56 (22).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US08524766B2 |
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| Quelldatensatz | uspto-grants-2013_09 |
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| ORD ID | ord-d687c40677da413283cac18f46317362 |
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| Quellennotiz | uspto-grants-2013_09 |
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