HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Tributylvinyltin → 2-(4-Fluorophenyl)-1-(2-cyclopentylamino-4-pyrimidinyl)-5-vinylimidazo[4,5-b]pyridine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Tributylvinyltin | HCID 81998 | — |
| Edukt | 5-Chloro-2-(4-fluorophenyl)-1-(2-cyclopentylamino-4-pyrimidinyl)imidazo[4,5-b]pyridine | HCID 22486152 | — |
| Katalysator | HCID 178418476 | HCID 178418476 | — |
| Lösungsmittel | O-Xylene | HCID 7237 | — |
| Produkt | 2-(4-Fluorophenyl)-1-(2-cyclopentylamino-4-pyrimidinyl)-5-vinylimidazo[4,5-b]pyridine | HCID 22486133 | 87,4% |
Reaktionsbedingungen
| Temperatur | 160 °C |
|---|
Reaktionsschritte
2-(4-Fluorophenyl)-1-(2-cyclopentylamino-4-pyrimidinyl)-5-chloroimidazo[4,5-b]pyridine (50 mg 0.12 mmol), vinyltributylstannane (4.3 ml 0.15 mmol) and PdCl2(PPh3)2 (8.6 mg 0.01 mmol) are dissolved in xylene (1 ml) and heated to 160° C. for 1 h under argon. The reaction mixture is purified over SiO2 (acetone/hexanes 15/85) to yield the title compound as colorless crystals (42 mg 86%)
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06608072B1 |
| Quelldatensatz | uspto-grants-2003_08 |
| ORD ID | ord-fc813a0ea39c43709d727a5df67106ae |
| Quellennotiz | uspto-grants-2003_08 |