HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Ammonia → HCID 178508933, Verbindung
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Ammonia | HCID 222 | — |
| Edukt | 2-((Acetyloxy)methoxy)ethyl acetate | HCID 100999 | — |
| Edukt | Diacetylguanine | HCID 136360183 | — |
| Lösungsmittel | Dimethyl Sulfoxide | HCID 679 | — |
| Produkt | HCID 178508933 | HCID 178508933 | — |
Reaktionsschritte
Matsumoto in Chem Pharm Bull, 36(3), 1153-1157 and JP 63-107982 teaches a process for the synthesis of acyclovir(Ia) by condensation of diacetyl guanine (DAG Va) with 2-oxa-1,4-butanediol diacetate (OBDDA, VIIa) in DMSO in presence of an acid catalyst to get a mixture of N-9/N-7 isomer (66:26). The former is isolated by column chromatography and deacetylated with methanolic ammonia to give acyclovir. Overall yield of acyclovir from guanine is 42%
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05821367 |
| Quelldatensatz | uspto-grants-1998_10 |
| ORD ID | ord-5825b520528642f6bbfe1b0fcb252da6 |
| Quellennotiz | uspto-grants-1998_10 |