HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Sodium Carbonate → N-(3,4-Difluorobenzyl)-6-(3,5-dimethylisoxazol-4-yl)-2-isopropyl-1-(pyridin-2-ylmethyl)-1H-indole-3-carboxamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Sodium Carbonate | HCID 10340 | — |
| Edukt | Lithium Chloride | HCID 433294 | — |
| Edukt | 3,5-Dimethylisoxazole-4-boronic acid | HCID 2734346 | — |
| Edukt | 3-(3,4-Difluorobenzylcarbamoyl)-2-isopropyl-1-(pyridin-2-ylmethyl)-1H-indol-6-yl trifluoromethanesulfonate | HCID 86621607 | — |
| Katalysator | HCID 178418397 | HCID 178418397 | — |
| Produkt | N-(3,4-Difluorobenzyl)-6-(3,5-dimethylisoxazol-4-yl)-2-isopropyl-1-(pyridin-2-ylmethyl)-1H-indole-3-carboxamide | HCID 59762407 | — |
Reaktionsschritte
Following General Procedure BB, 3-(3,4-difluorobenzylcarbamoyl)-2-isopropyl-1-(pyridin-2-ylmethyl)-1H-indol-6-yl trifluoromethanesulfonate (Compound 202, 57 mg, 0. 10 mmol), was reacted with 3,5-dimethylisoxazol-4-ylboronic acid (21 mg, 0.15 mmol), LiCl (13 mg, 0.30 mmol), Na2CO3 (aqueous) (2M, 0.2 ml), Pd(PPh3)4 (6 mg, 0.006 mmol) to yield the title compound as a yellow solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08524917B2 |
| Quelldatensatz | uspto-grants-2013_09 |
| ORD ID | ord-eca5c57f77234fc086ade766493d1162 |
| Quellennotiz | uspto-grants-2013_09 |