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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 402804Erstellt: 24. Oktober 2026

Potassium Carbonate → 6-Cyclopropyl-2,2-dimethylchroman-8-carbaldehyde

https://huagongshe.com/de/reaction/402804

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
EduktPotassium CarbonateHCID 11430—
Edukt2-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenylHCID 11155794—
EduktPotassium cyclopropyltrifluoroborateHCID 23697338—
Edukt6-Chloro-2,2-dimethylchroman-8-carbaldehydeHCID 77230853—
Katalysatorpalladium(II) acetateHCID 167845—
Produkt6-Cyclopropyl-2,2-dimethylchroman-8-carbaldehydeHCID 77230852—

Reaktionsschritte

Using essentially the same procedure as Example 5-22, Step 4, Pd(OAc)2 (7.04 mg, 0.03 mmol), X-Phos (29.9 mg, 0.06 mmol), potassium carbonate (434 mg, 3.14 mmol), potassium cyclopropyltrifluoroborate (170 mg, 1.15 mmol) and 6-chloro-2,2-dimethyl-3,4-dihydro-2H-chromene-8-carbaldehyde (235 mg, 1.05 mmol, Example 5-26, Step 3) afforded the desired product as a pale-yellow oil.

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS08742110B2
Quelldatensatzuspto-grants-2014_06
ORD IDord-6ccc0aa3f9044d488b96aefe37ec5959
Quellennotizuspto-grants-2014_06