HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea → (S)-Methyl 2-(1-oxo-5-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)isoindolin-2-yl)-2-phenylacetate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea | HCID 16125103 | — |
| Edukt | Methyl 1-(5-bromo-1-oxoisoindolin-2-yl)cyclopentanecarboxylate | HCID 67313405 | — |
| Edukt | (R)-Methyl 3-methyl-2-(1-oxo-5-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)isoindolin-2-yl)butanoate | HCID 131731536 | — |
| Katalysator | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | (S)-Methyl 2-(1-oxo-5-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)isoindolin-2-yl)-2-phenylacetate | HCID 131731539 | — |
Reaktionsschritte
The compound of example 372 was prepared analogous to compound of example 360 by reaction of the compound of example 371, compound of example 357 and Pd(dppf)Cl2: CH2Cl2.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08748426B2 |
| Quelldatensatz | uspto-grants-2014_06 |
| ORD ID | ord-01c7d7de7ed449c9a253d0e93f0d7788 |
| Quellennotiz | uspto-grants-2014_06 |