HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Methylamine → 2-((Methylamino)methyl)fluorene
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Methylamine | HCID 6329 | — |
| Edukt | N-methyl fluorene-2-carboxamide | HCID 10704314 | — |
| Edukt | 9H-Fluorene-2-carbonyl chloride | HCID 17815629 | — |
| Edukt | Aluminium lithium hydride | HCID 21226445 | — |
| Lösungsmittel | Diethyl Ether | HCID 3283 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Produkt | 2-((Methylamino)methyl)fluorene | HCID 12689751 | — |
Reaktionsschritte
A solution of fluorene-2-carbonyl chloride (prepared from fluorene-2-carboxylic acid and oxalyl chloride) in THF is added to aqueous methylamine (2 molar equivalents) to prepare N-methyl fluorene-2-carboxamide. Reduction of the amide using LiAlH4 in ether provides 2-((methylamino)methyl)fluorene. The amine is protected by reaction with di-tert-butyl dicarbonate to provide 2-((N-tBOC-N-methylamino)methyl)fluorene.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08754190B2 |
| Quelldatensatz | uspto-grants-2014_06 |
| ORD ID | ord-3f949e3bfb8446e29e8001a6d1168c47 |
| Quellennotiz | uspto-grants-2014_06 |