Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | 2-Amino-6-methylpyrimidin-4-one | HCID 135402055 | — |
| Edukt | 2-Aminoisocytosine | HCID 135408763 | — |
| Edukt | 2-Methyl-4-amino-6-hydroxypyrimidine | HCID 135431330 | — |
| Edukt | 2-Amino-6-methyl-1,7-dihydropyrrolo[2,3-d]pyrimidin-4-one | HCID 135453810 | — |
| Edukt | 4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-ylmethyl)-amino]-benzoic acid | HCID 135515391 | — |
| Edukt | 2,5-Diaminothiazolo(4,5-d)pyrimidin-7-(6H)-one | HCID 135554446 | — |
| Edukt | 2-Amino-5-{[4-(4-amino-benzyl)-phenylamino]-methyl}-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one | HCID 136050867 | — |
| Edukt | 2-amino-8-sulfanyl-3,7-dihydropurin-6-one | HCID 178508258 | — |
| Produkt | Pteroic Acid | HCID 135398749 | — |
Reaktionsschritte
The Artemia salinas ribosome in vitro protein synthesis assay was used to analyze the effects of 2,6-diamino-3H-pyrimidin-4-one 1, 2-amino-6-dihydroxy-5-methylpyrimidin-4-one 25, 2-amino-6-methylpyrimidin-4-one 26, 6-amino-2-methyl-3H-pyrimidin-4-one 27, 2-amino-8-mercapto-1,9-dihydro-purin-6-one 28, 2,5-diamino-6H-thiazolo[4,5-d]pyrimidin-7-one 14, 4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-ylmethyl)-amino]-benzoic acid 21, 2-amino-5-{[4-(4-amino-benzyl)-phenylamino]-methyl}-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one 24, and 2-amino-6-methyl-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one 6 on ricin activity. The results are presented in FIG. 23. 2-amino-6-methyl-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one 6 was the most effective inhibitor with an IC50 of 0.25 mM.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US06562969B1 |
|---|
| Quelldatensatz | uspto-grants-2003_05 |
|---|
| ORD ID | ord-a4866d61dbf64e61af1a61054a53d068 |
|---|
| Quellennotiz | uspto-grants-2003_05 |
|---|
