HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-3,1-benzoxazin-6-yl)boronic acid → 5-(4,4-dimethyl-2-oxo-1,4-dihydro-2H-3,1-benzoxazin-6-yl)-4-methylthiophene-2-carbonitrile
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | (4,4-Dimethyl-2-oxo-1,4-dihydro-2H-3,1-benzoxazin-6-yl)boronic acid | HCID 10987806 | — |
| Edukt | 5-Bromo-4-methylthiophene-2-carbonitrile | HCID 21986234 | — |
| Produkt | 5-(4,4-dimethyl-2-oxo-1,4-dihydro-2H-3,1-benzoxazin-6-yl)-4-methylthiophene-2-carbonitrile | HCID 9814768 | — |
Reaktionsschritte
Prepared according to Procedure B from (1,4-dihydro-4,4-dimethyl-2-oxo-2H-3,1-benzoxazin-6-yl)boronic acid and 5-bromo-4-methyl-2-thiophenecarbonitrile. Off-white solid: mp 195-200° C. 1H-NMR (DMSO-d6) δ10.2 (s, 1H), 8.32 (s, 1H), 7.41-7.44 (m, 2H), 7.01 (d, 1H, J=8.8 Hz), 2.28 (S, 3H), 1.64 (S, 6H); MS (APCI) m/z 299 [M+H]+. Anal. Calc. For C16H14N2O2S; C, 64.41; H, 4.75; N, 8.89. Found: C, 64.64; H, 4.62; N, 9.39.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06566358B2 |
| Quelldatensatz | uspto-grants-2003_05 |
| ORD ID | ord-1d4c640bab4644a8a6d257bd177bf896 |
| Quellennotiz | uspto-grants-2003_05 |